Rnf8 Induces Beta-Catenin-Mediated C-Myc Expression And Promotes Colon Cancer Proliferation
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES(2020)
摘要
DNA damage signals transducer RING finger protein 8 (RNF8) is involved in maintaining genomic stability by facilitating the repair of DNA double-strand breaks (DSB) via ubiquitin signaling. By analyzing the TCGA database and colon cancer tissue microarrays, we found that the expression level of RNF8 was positively correlated with that of c-Myc in colon cancer, which were closely associated with poor survival of colon cancer patients. Furthermore, overexpressing and knocking down RNF8 increased and decreased the expression of c-Myc in colon cancer cells, respectively. In addition, RNF8 interacted with beta-catenin and facilitated its nuclear translocation by conjugating K63 polyubiquitination on it. These observations suggested a de novo role of RNF8 in promoting the progression of colon cancer by inducing beta-catenin-mediated c-Myc expression.
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关键词
RNF8, c-Myc, beta-catenin, colon cancer
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