Ssociation Of Systemic Comorbities With Predominantly Peripheral Diabetic Retinopathy Lesions (Ppl) Identified On Ultrawide Field (Uwf) Retinal Imaging

Purpose: To evaluate the association of systemic comorbidities with presence of PPL on UWF imaging in eyes of patients with diabetes (DM).Methods: All Beetham Eye Institute UWF images and electronic medical records from 5/1/09-8/30/18 were reviewed. UWF images with no diabetic retinopathy (DR) or any level of nonproliferative DR (NPDR) were evaluated using an automated hemorrhage and/or microaneurysm (HMA) detection algorithm to determine HMA count and location within, and peripheral to, the ETDRS 7 fields. Algorithm performance AUC against manual MA identification was 0.90-0.95 for images with NPDR. PPL-HMA were defined as present when at least 1 field had greater HMAs number in the peripheral retina than within the ETDRS fields.Results: Images and records from 13,015 eyes with gradable UWF were studied. Mean age was 57.5±17.1 yrs, DM duration 21.0±10.6 yrs, 2-year mean …