Identification and characterization of chemical constituents in Qi-Lin pills and their metabolites in rat bio-samples after oral administration using ultra-high performance liquid chromatography with quadrupole time-of-flight mass spectrometry.

•The chemical profile of QLP and its metabolites were characterized based on data analysis strategy with UPLC/Q-TOF-MS.•A total of 202 constituents contained fifteen herbal medicines were identified in QLP extract.•The metabolic characteristics of QLP in rats were explored.•76 prototypes and 127 related metabolites were characterized in rat bio-samples after oral administration of QLP.