Retinoids and Developmental Neurotoxicity: utilizing toxicogenomics to enhance adverse outcome pathways and testing strategies.

•Review of retinoic acid (RA) signaling and developmental neurotoxicity (DNT).•Defined an adverse outcome pathway (AOP) related to imbalances in RA and DNT.•By integrating diverse datasets, identified genes associated with RA exposure and DNT.•This gene set, when applied to the zebrafish model, yielded shared targets of RA.•Demonstrated application of RA-signature in AOP framework and chemical screening