Investigation of binary and ternary solvent systems for dermal delivery of methadone.
International Journal of Pharmaceutics(2020)
摘要
•A good correlation (r2 = 0.80) for methadone permeation was obtained between porcine ear skin and human skin.•Propylene glycol increased the skin permeation of Transcutol® in porcine skin and human skin.•Synergistic actions between propylene glycol and Transcutol® on the penetration enhancement of methadone were observed.•Methadone appears to “track” the permeation of Transcutol®.
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关键词
NMDA,LIM,EO,TC,OSAL,IPA,PG,HPLC,OA,PGML,WL 1349,PBS,DVS,RH,GC,FID,LOD,LOQ,ICH,OECD,SD,ANOVA,TriPG
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