The L1 cell adhesion molecule affects protein kinase D1 activity in the cerebral cortex in a mouse model of Alzheimer's disease.

Shuangxi Chen,Qiong Jiang,Peizhi Huang,Chengliang Hu,Huifan Shen,Melitta Schachner,Weijiang Zhao

Brain Research Bulletin（2020）

引用 16|浏览10

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摘要

•L1CAM (L1) increases levels of phosphorylated protein kinase D1 (PKD1).•L1 and pPKD1 levels are increased in APPSWE mice.•L1 and pPKD1 levels correlate positively in cultured mouse cortical neurons.•L1 and pPKD1 ameliorate stress-induced cortical neuronal cell death.

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关键词

Alzheimer’s disease (AD),Cerebral cortex,L1 cell adhesion molecule (L1CAM),Neuronal cell death,Protein kinase D1 (PKD1)

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