Myricetin ameliorates bleomycin-induced pulmonary fibrosis in mice by inhibiting TGF-β signaling via targeting HSP90β.

Xiaohe Li,Haiyan Yu,Lu Liang,Zhun Bi,Yanhua Wang,Shaoyan Gao,Mukuo Wang,Hailong Li,Yang Miao,Ruxia Deng,Ling Ma,Jiaoyan Luan,Shuangling Li,Menghan Liu,Jianping Lin,Honggang Zhou,Cheng Yang

Biochemical Pharmacology（2020）

引用 34|浏览46

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摘要

Myricetin targeting HSP90β to blocking TGF-β/Smad and non-Smad signaling pathway, and then inhibiting fibroblasts activation and EMT process, subsequently ameliorates bleomycin-induced pulmonary fibrosis in mice.

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关键词

Pulmonary fibrosis,Myricetin,TGF-β signaling pathway,HSP90β

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