Increased TLR4 pathway activation and cytokine imbalance led to lipopolysaccharide tolerance in monocytes from preeclamptic women.

•Increased TLR4 expression and NF-κB activation in monocytes from preeclamptic women.•Monocytes activation in preeclampsia may depend on elevated plasmatic danger signals.•LPS tolerance may be directly related to the higher DAMPs levels in the plasma.•Cytokine imbalance between normotensive and preeclamptic pregnant women.•Preeclamptic women monocytes show lower activation after stimulation with LPS.