Characterization of cyclooxygenase-2 acetylation and prostanoid inhibition by aspirin in cellular systems.

Stefania Tacconelli,Annalisa Contursi,Lorenza Falcone,Matteo Mucci,Ilaria D'Agostino,Rosa Fullone,Angela Sacco,Mirco Zucchelli,Annalisa Bruno,Patrizia Ballerini,Melania Dovizio,Paola Patrignani

Biochemical Pharmacology（2020）

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摘要

•We have developed a direct biomarker of aspirin action on COX-2.•It consists of the evaluation of the extent of COX-2 acetylation at serine-516.•It allows assessing COX-2 acetylation in isolated cells and cancerous lesions.•It permits clarifying the mechanism of action of aspirin as an anticancer agent.•It is a tool for a rational selection of aspirin dose for cancer patients.

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关键词

Cyclooxygenase-2,Aspirin,Prostaglandin E2,Acetylation,Monocytes,Epithelial cells

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