Lipid Metabolism Genes in Stroke Pathogenesis: The Atherosclerosis.
CURRENT PHARMACEUTICAL DESIGN(2020)
摘要
Stroke is the second leading cause of death and a major cause of disability worldwide. Both modifiable and non-modifiable risk factors can affect the occurrence of ischemic stroke at varying degrees. Among them, atherosclerosis has been well-recognized as one of the main culprits for the rising incidence of stroke-related mortality. Hence, the current review aimed to summarize the prominent role of lipid metabolism genes such as PCSK9, ApoB, ApoA5, ApoC3, ApoE, and ABCA1 in mediating ischemic stroke occurrence.
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关键词
Lipids,gene,stroke,metabolism,PCSK9,ApoB,ApoA5,ApoC3,ApoE,ABCA1
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