Transcription factor AP2A affects sFLT1 expression and decidualization in decidual stromal cells: Implications to preeclampsia pathology.
Pregnancy Hypertension(2020)
摘要
•DSCs of PE women exhibit 6-fold higher levels of TFAP2A mRNA.•TFAP2A may play a repressor role in sFlt1 expression in DSCs that is affected in PE-DSCs.•TFAP2A is required for decidualization of both NT- and PE-DSCs.
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关键词
PE,NT,DSC,MFI,sFLT1,VEGF,IGFBP1,PRL
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