Exon skipping of TGFβRI affects signalling and ECM expression in hypertrophic scar-derived fibroblasts.

Rajiv S Raktoe,Marion H Rietveld,Jacoba J Out-Luiting,Marianna Kruithof-de Julio,Paul Pm van Zuijlen,Remco van Doorn,Abdoelwaheb El Ghalbzouri

Scars, burns & healing（2020）

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摘要

Exon skipping is a promising tool to modulate the TGF-β signalling pathway in HS. This would open a therapeutic window for the treatment of patients suffering from HSs.

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关键词

(myo)fibroblasts,ALK5,Hypertrophic scars,TGF-β,antisense oligonucleotides,exon skipping

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