In vitro Treatment of a Murine Mammary Adenocarcinoma Cell Line with Recombinant Trypanosoma cruzi Calreticulin Promotes Immunogenicity and Phagocytosis.

Eduardo Sosoniuk-Roche, Pamela Cruz,Ismael Maldonado, Leonora Duaso, Bárbara Pesce,Marek Michalak,Carolina Valck,Arturo Ferreira

Molecular Immunology（2020）

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摘要

•rTcCalr binds to cells of a mammary adenocarcinoma cell line (TA3 cells).•C1q binds both rTcCalr dependently and independently to TA3 cells.•rTcCalr promotes TA3 cells phagocytosis by macrophages.•rTcCalr modulates immune relevant molecules such as MHC II, Galectin-9 and Rae-1γ.

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关键词

Cancer,Trypanosoma cruzi,Calreticulin,Immunomodulation

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