Zoledronic acid inhibits thyroid cancer stemness and metastasis by repressing M2-like tumor-associated macrophages induced Wnt/β-catenin pathway.

•M2-like TAMs are enriched in human TC tissues, and promotes TC cells proliferation, migration, invasion and stemness.•ZA weakens the progression of TC cells by inhibition M2-like TAMs.•ZA inhibits β-catenin entry into the nucleus and activation of Wnt/β-catenin pathways induced by M2-like TAMs.•ZA reduces subcutaneous tumor formation and macrophage enrichment in vivo.