New Phenotypic Cytotoxicity Assay for ROS-inducing Compounds using Rat Renal Epithelial Cells.

Noriko Uchiyama,Tomoya Yukawa,Yvonne P Dragan,Matthew P Wagoner,Russell T Naven

Toxicology Letters（2020）

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摘要

•Induction of oxidative stress is an important mechanism of chemical toxicity.•Developed prediction assay of NOX-mediated ROS production with NRK52E and HepG2.•A combination was superior to prediction of in vivo toxicity than only one cell.•NRK52E viability followed up to aid in selection of compounds for in vivo toxicity.

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关键词

In vitro cytotoxicity,Reactive oxygen species (ROS),NADPH oxidase (NOX),In vivo safety studies

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