Organoid modelling identifies that DACH1 functions as a tumour promoter in colorectal cancer by modulating BMP signalling

Long Zhang
Long Zhang
Yaqi Li
Yaqi Li
Xiaoxue Gao
Xiaoxue Gao
Xinxin Rao
Xinxin Rao
Guoxiang Fu
Guoxiang Fu
Renjie Wang
Renjie Wang
Mengxue Pan
Mengxue Pan
Qiang Guo
Qiang Guo
Xiaoya Xu
Xiaoya Xu

EBioMedicine, pp. 1028002020.

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Keywords:
BMP signalling pathwayColorectal cancerDACH1OrganoidStem cells

Abstract:

Together, our study highlights DACH1 as an integral regulator of BMP signalling during intestinal tumorigenesis, and DACH1 could be a potential prognostic marker and therapeutic target for colorectal cancer patients.

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