Organoid modelling identifies that DACH1 functions as a tumour promoter in colorectal cancer by modulating BMP signalling.

Xiang Hu,Long Zhang,Yaqi Li,Xiaoji Ma,Weixing Dai,Xiaoxue Gao,Xinxin Rao,Guoxiang Fu,Renjie Wang,Mengxue Pan,Qiang Guo,Xiaoya Xu,Yi Zhou,Jianjun Gao,Zhen Zhang,Sanjun Cai,Junjie Peng,Guoqiang Hua

EBioMedicine（2020）

引用 19|浏览86

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摘要

Together, our study highlights DACH1 as an integral regulator of BMP signalling during intestinal tumorigenesis, and DACH1 could be a potential prognostic marker and therapeutic target for colorectal cancer patients.

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关键词

DACH1,Organoid,Stem cells,BMP signalling pathway,Colorectal cancer

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