Hippo Signaling in Regeneration and Aging.

Mechanisms of Ageing and Development（2020）

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摘要

•The transcriptional coactivator YAP and its paralogue TAZ are the downstream transducers of the Hippo pathway.•YAP/TAZ are essential to repair tissue after damage.•Induction of YAP/TAZ could be an attractive approach to enhance regeneration, e.g. during aging.•Manipulation of YAP/TAZ activity is promising for regenerative medicine.

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关键词

Hippo pathway,YAP/TAZ,Aging,Stem cells,Regeneration

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