Inhibition of β-glucosidase overcomes gastric cancer chemoresistance through inducing lysosomal dysfunction

Zheng Li,Dongqiang Xu,Xudong Tong, Changxing Shan

Clinics and Research in Hepatology and Gastroenterology（2021）

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摘要

•GBA1 is activated in gastric cancer cell response to chemotherapy.•GBA1 inhibition sensitizes gastric cancer cell to chemotherapy.•GBA1 inhibition suppresses growth and survival but not migration in gastric cancer.•GBA1 inhibition induces lysosomal dysfunction in gastric cancer cells.

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关键词

Gastric cancer,β-glucosidase,GBA,Chemoresistance,Lysosome function

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