Clinical and Molecular Correlates of Tumor Mutation Burden in Non-Small Cell Lung Cancer

Michael F. Sharpnack,Ju Hwan Cho,Travis S. Johnson,Gregory A. Otterson, Peter G. Shields,Kun Huang,David P. Carbone,Kai He

Lung Cancer（2020）

引用 12|浏览65

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摘要

•Smoking history is not a surrogate biomarker for tumor mutation burden•We create a predictive model of tumor mutation burden•We discover genome stability genes associated with high tumor mutation burden, including REV3L.

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关键词

TMB,TSH,LUAD,GSG,LUSC,NSCLC,ICI,MMR,TCGA,SPY

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