Endurance training exerts time-dependent modulation on depressive responses and circadian rhythms of corticosterone and BDNF in the rats with pinealectomy.

•Endurance training attenuated depressive responses in rats with pinealectomy.•Exercise increased the maximal time to exhaustion both in sham and pin rats.•Exercise corrected and decreased flattened pattern of corticosterone in pin rats.•Endurance training induced a great and time-dependent increase in hippocampal BDNF.