The small molecule P7C3-A20 exerts neuroprotective effects in a hypoxic-ischemic encephalopathy model via activation of PI3K/AKT/GSK3β signaling.

Junjie Bai,Shanshan Zeng,Jinjin Zhu,Changchang Fu,Minzhi He,Jianghu Zhu, Shangqing Chen,Xiaoqin Fu,Peijun Li,Zhenlang Lin

Neuroscience（2020）

引用 6|浏览43

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摘要

•P7C3-A20 could decrease brain atrophy and alleviate apoptosis after HI injury.•P7C3-A20 could improve the prognosis after HI injury.•P7C3-A20 has not been found toxic effects on other organs of newborn rats.•P7C3-A20 exerted neuroprotection via the PI3K/ Akt/GSK3β pathway.

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关键词

AKT,Bax,Bcl-2,CCK-8,DMEM,FBS,GSK3β,HIE,MAP2,MBP,MCL-1,OGD,PFA,PI3K,TTC,TUNEL

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