Characterising lipoteichoic acid as an in vitro model of acute neuroinflammation.

Anne-Marie Howe, Aoife Cosgrave, Maitiú Ó'Murchú, Conor Britchfield, Aoife Mulvagh, Iván Fernandez-Perez, Megan Dykstra,Aimée C Jones,Derek A Costello

International Immunopharmacology（2020）

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摘要

•Exposure to LTA can induce inflammatory changes in both microglia and neuronal cells.•LTA and Aβ synergise to promote microglial activation and activity of hippocampal neurons.•The flavonoid agent 7,8,3-THF attenuates LTA-induced activation of BV2 microglial cells.

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关键词

TLR2,BV2,β-amyloid,Hippocampus,Nitric oxide,Cytokines,BDNF, 7,8,3-THF

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