Hypoxia causes sex-specific hepatic toxicity at the transcriptome level in marine medaka (Oryzias melastigma).

•Hypoxia cause differential gene expression in fish liver.•Hypoxia may lead to liver inflammation in both male and female fish.•Sex-specific hepatic responses in fish through different cell signaling pathways.•Hypoxia may interrupt the structure of the endoplasmic reticulum in female fish liver.•Hypoxia may interrupt redox homeostasis and fatty acid metabolism in male fish liver.