Total Synthesis and Biological Evaluation of Kakeromamide A and Its Analogues.

Meng Zhao,Yi Xiao,Satoshi Otsuka,Yoichi Nakao,Yian Guo,Tao Ye

FRONTIERS IN CHEMISTRY（2020）

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摘要

Kakeromamide A (1), the first marine cyclopeptide inducing neural stem cells differentiation into astrocytes, was synthesized in 12 longest linear steps and 14% overall yield. Using this synthetic approach, four analogs of kakeromamide A were prepared and evaluated for neural differentiation- modulating activity.

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关键词

kakeromamide A,total synthesis,biological evaluations,marine cyclopeptide,structural analogs

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