HuR promotes miRNA-mediated upregulation of NFI-A protein expression in MDSCs during murine sepsis.

Isatou Bah,Tuqa Alkhateeb,Ajinkya Kumbhare,Dima Youssef,Zhi Q Yao,Gregory A Hawkin,Charles E McCall,Mohamed El Gazzar

Molecular Immunology（2020）

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摘要

•A mechanism for miRNA-mediated upregulation of NFI-A in MDSCs during sepsis is proposed.•HuR couples with miR-21 and miR-181b to stabilize NFI-A mRNA and increases its protein level in MDSCs.•CUGBP1 destabilizes NFI-A mRNA in the absence of miR-21 and miR-181b.

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关键词

MDSC,Sepsis,miRNA,NFI-A

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