Gellan gum-based hydrogel containing nanocapsules for vaginal indole-3-carbinol delivery in trichomoniasis treatment.

Bárbara Felin Osmari,Laura Minussi Giuliani,Jéssica Brandão Reolon,Graziela Vargas Rigo,Tiana Tasca,Letícia Cruz

European Journal of Pharmaceutical Sciences（2020）

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摘要

•NC-I3C showed enhanced anti-Trichomonas vaginalis activity in vitro.•Hydrogel was obtained by thickening NC-I3C with gellan gum.•Gellan gum hydrogel containing NC-I3C was suitable for vaginal administration.•Gellan gum hydrogel containing NC-I3C is promising for trichomoniasis treatment.

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关键词

Nanoparticles,Trichomonas vaginalis,Diindolylmethane,Mucoadhesion,Semisolids

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