MUC1 plays an essential role in tumor immunity of colorectal cancer stem cell vaccine.

Mei Guo,Biao Luo,Meng Pan,Miao Li,Fengshu Zhao,Jun Dou

International Immunopharmacology（2020）

引用 24|浏览11

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摘要

•CCSC vaccine exerts anti-tumor immunity against CRC.•MUC1 may play an important role in CD133+ CCSCs.•MUC1 downregulation attenuates the effects of CD133+ CCSC vaccine.•CCSC vaccine reveals non-toxicity to organs of mice.

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关键词

Colorectal cancer,Cancer stem cell,MUC1,Vaccine,Tumor immunity

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