Bovine lactoferrin enhances osteogenesis through Smad2/3 and p38 MAPK activation.

Toshihiro Inubushi, Azuma Kosai, Shyunryo Yanagisawa,Chea Chanbora,Mutsumi Miyauchi,Satoshi Yamasaki,Eiji Sugiyama,Atsushi Ishikado,Taketoshi Makino,Takashi Takata

Journal of Oral Biosciences（2020）

引用 14|浏览40

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摘要

•Bovine lactoferrin enhances osteogenic differentiation of mesenchymal stem cells.•Bovine lactoferrin activates Smad2/3 and p38 MAPK signaling pathway.•Bovine lactoferrin enhances bone regeneration in ex vivo organ cultures of calvariae.•Inhibition of Smad2/3 or p38 MAPK signaling diminished the anabolic effects of bovine lactoferrin.

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关键词

Lactoferrin,Osteogenesis,Growth factor(s),Bone remodeling/regeneration,Smad

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