Activation of SREBP-1c alters lipogenesis and promotes tumor growth and metastasis in gastric cancer.

•SREBP-1c is oncogenic via fatty acid and lipid synthesis alters lipogenesis.•Fatty acid related metabolic synthetase is required for tumorigenesis.•Specific fatty acid of palmitic acid is a tumor suppressor gene in fatty acid metabolism.•Inhibition of SREBP-1c is a potential strategy in the treatment of Gastric cancer.