Inhibition of Striatal-Enriched Protein Tyrosine Phosphatase (STEP) Activity Reverses Behavioral Deficits in a Rodent Model of Autism.

Manavi Chatterjee,Priya Singh,Jian Xu,Paul J Lombroso,Pradeep K Kurup

Behavioural Brain Research（2020）

引用 3|浏览19

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摘要

•In utero valproic acid administration induced increased STEP expression in mice.•Increased STEP activation led to dephosphorylation of GluN2B, Pyk2 and ERK1/2.•STEP Inhibitor, TC-2153 rescued the autistic-like behaviors in VPA exposed pups.

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关键词

Valproic acid,STEP,TC-2153,Autism,Repetitive behavior,Social interaction

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