Pharmacological targeting of striatal indirect pathway neurons improves subthalamic nucleus dysfunction and reduces repetitive behaviors in C58 mice.

Amber M Muehlmann,Sebastian Maletz,Michael A King,Mark H Lewis

Behavioural Brain Research（2020）

引用 9|浏览5

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摘要

•C58 mice exhibit high rates of repetitive behavior.•Reduced indirect pathway activation mediates repetitive behavior in C58 mice.•A drug cocktail targeting indirect pathway reduced repetitive behavior in C58 mice.•The drug cocktail increased biochemical and anatomical markers of STN activation.

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关键词

Neurodevelopmental disorders,Repetitive behavior,Obsessive compulsive disorder,Autism spectrum disorder,Subthalamic nucleus,Indirect pathway,Basal ganglia

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