Tetramethylpyrazine attenuates endotoxin-induced retinal inflammation by inhibiting microglial activation via the TLR4/NF-κB signalling pathway.

Xiaokun Han,Xi Chen,Shuilian Chen,Qian Luo,Xuan Liu,Anqi He,Shengyu He,Jin Qiu,Pei Chen,Yihui Wu,Jiejie Zhuang,Meng Yang,Chuangran Wu,Nandan Wu,Ying Yang,Jian Ge,Jing Zhuang,Keming Yu

Biomedicine & Pharmacotherapy（2020）

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摘要

•Tetramethylpyrazine inhibits the activation of retinal microglial cells.•Tetramethylpyrazine suppresses microglial activation through TLR4/NF-κB signalling.•Tetramethylpyrazine inhibits apoptosis in retinal neuroprotection.

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关键词

TMP,LPS,EIU,Iba1,TLR4,NF-κB,Bcl-2,Bax,IκB-α,IL,TNF-α,CXCR4,AMD,GCL,OPL,ONL,IPL,INL,LBP

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