Decreased cerebrospinal fluid neuronal pentraxin receptor is associated with PET-Aβ load and cerebrospinal fluid Aβ in a pilot study of Alzheimer's disease.

Bryant Lim,Qiao-Xin Li,Christopher Rowe,Kunal Dhiman,Veer Bala Gupta,Colin L Masters,James D Doecke,Ralph N Martins,Steven Collins,Eleftherios P Diamandis

Neuroscience Letters（2020）

引用 5|浏览41

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摘要

•Neuronal pentraxin receptor (NPTXR) is a preclinical AD biomarker.•CSF NPTXR levels differs in PET-amyloid positive and negative individuals.•CSF NPTXR strongly associated with AD CSF biomarkers, β-amyloid and tau species.•CSF neurofilament light is not informative in preclinical AD.

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关键词

Alzheimer’s disease,Cerebrospinal fluid,Neuronal pentraxin receptor,Positron emission tomography,Aβ-amyloid,Neurofilament light

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