Omega-3 derivatives, specialized pro-resolving mediators: Promising therapeutic tools for the treatment of pain in chronic liver disease.

•Liver Chronic disease is the 11th leading cause of mortality.•There is not a well-designed treatment for chronic liver disease except transplantation.•Specialized pro-resolving molecules play a role as anti-inflammatories and resolution in liver disease•Pain in Liver chronic disease is still a clinical challenge•Specialized pro-resolving molecules are interesting endogen molecules for treatment of pain and inflammation in liver disease