A review on possible modes of action of chloroquine/hydroxychloroquine: repurposing against SAR-CoV-2 (COVID-19) pandemic
International Journal of Antimicrobial Agents(2020)
摘要
•Chloroquine (CQ) has diverse modes of action against viral infections.•CQ may interfere with SARS-CoV-2 attachment to the host ACE2 receptor.•CQ may hamper the STING pathway to attenuate the pro-inflammatory response.•Hydroxychloroquine (HCQ) might be a logical approach in the treatment of SARS-CoV-2 infection.•Large clinical trials are needed before clinical recommendations of HCQ against COVID-19.
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关键词
COVID-19,SARS-CoV-2,Chloroquine,Hydroxychloroquine,Pandemic
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