Tumor-targeted dose escalation for localized prostate cancer using MR-guided HDR brachytherapy (HDR) or integrated VMAT (IB-VMAT) boost: Dosimetry, toxicity and health related quality of life.

Noelia Sanmamed,Jenny Lee,Alejandro Berlin,Tim Craig,Bernadeth Lao,Alexandra Rink,Andrew Bayley,Charles Catton,Aravindhan Sundaramurthy, WarrenFoltz,Andrew McPartlin,Sangeet Ghai,Mary Gospodarowicz,Padraig Warde,Cynthia Ménard,Peter Chung

Radiotherapy and Oncology（2020）

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摘要

•Intraprostatic tumor dose escalation using IB-VMAT or MR-guided HDR boost is feasible.•IB-VMAT and HDR boost achieve comparable dosimetry, toxicity and HRQOL outcomes.•HDR boost achieved higher mean and maximal GTV doses than IB-VMAT.

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关键词

Dose escalation,VMAT,HDR,MRI-guided,Toxicity,Quality of life,Prostate Cancer

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