Inter-Individual Differences in the Responses to Pain Neuroscience Education in Adults With Chronic Musculoskeletal Pain: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

•Pain neuroscience education is a pain management intervention.•Little evidence of true individual differences in response to pain neuroscience education for disability.•Findings should be interpreted cautiously due to very wide prediction intervals.•Estimating individual differences should be applied to other pain interventions.