Multiple MuSK signaling pathways and the aging neuromuscular junction

Neuroscience Letters（2020）

引用 16|浏览5

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摘要

•The NMJ becomes unstable with age.•Many NMJ aging phenotypes are shared between rodents and humans, but key differences are observed.•MuSK participates in three signaling pathways: Agrin-LRP4, Wnt and MuSK-BMP, via distinct domains.•Determining the roles of these three pathways in synapse stability could open new pathways for therapeutic intervention.

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关键词

Neuromuscular junction,MuSK,Synaptic maintenance,Aging,BMP signaling

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