Efficient microbial resolution of racemic methyl 3-cyclohexene-carboxylate as chiral precursor of Edoxaban by newly identified Acinetobacter sp. JNU9335

Enzyme and Microbial Technology（2020）

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摘要

•A new strain Acinetobacter sp. JNU9335 was identified by target-oriented enrichment•Isooctane/aqueous biphasic system was favorable for kinetic resolution of rac-CHCM•As high as 1.0 M rac-CHCM could be stereoselectively hydrolyzed into (S)-CHCM.

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关键词

(S)-3-Cyclohexene-1-carboxylic acid,Genome data mining,Acinetobacter sp. JNU9335,Kinetic resolution,Isooctane/aqueous biphasic system

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