Mixed Oxides as Successful Sorption Materials for Some Active Pharmaceutical Ingredients

Mixed oxides based on Mg-Al, Mg-Fe, Zn-Al, and Ni-Mg-Al were prepared, characterized and used as sorption materials for different types of active pharmaceutical ingredients (APIs)- nicotinic acid, salicylic acid, ibuprofen, paracetamol and ascorbic acid. Immobilization of APIs on solid supports was confirmed using X-Ray diffraction and infrared spectroscopy. Overall, the best sorption material for mentioned substances showed to be mixed Mg-Al oxides (>80 % of immobilized substance after 4 h except ascorbic acid). On the other hand, Mg-Fe and Mg-Ni-Al materials did not possess high sorption capacity (max. 59 % after 4 h). From studied substances, the immobilization amount was the lowest in the case of ascorbic acid (max. 44 % immobilized after 4 h), the highest amount was immobilized in the case of salicylic and nicotinic acids (>95 %, 4 h). The discussion regarding the structure of substances and properties of sorption materials is also offered.