Versatile approach to densely substituted isoxazolines and pyrazolines: focus on a quaternary carbon center as a constitutive feature

Abderrahmen Abdelli,Haythem Gharsa, Momtez Jmaï,Anne Gaucher,Mohamed Lotfi Efrit,Hedi M'rabet,Damien Prim

Tetrahedron Letters（2020）

引用 12|浏览8

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摘要

•Synthesis of isoxazolines and pyrazolines from a common allylphosphonate starting material.•Easy access to C5 quaternary carbon center.•Selective 1,3-dipolar cycloaddition under mild conditions.•Specific antibacterial activity against Staphylococcus aureus strain.

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关键词

1,3-Dipolar cycloaddition,Isoxazolines,Pyrazolines,Staphylococcus aureus

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