Montelukast Potentiates the Antiinflammatory Effect of NSAIDs in the Rat Paw Formalin Model and Simultaneously Minimizes the Risk of Gastric Damage

Sherien A. Abdelhady,Mennatallah A. Ali,Tamer A. Al-Shafie,Ebtsam M. Abdelmawgoud,Dalia M. Yacout,Mahmoud M. El-Mas

FASEB JOURNAL（2021）

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摘要

While montelukast equally enhances antiinflammatory action of diclofenac or celecoxib via downregulating iNOS/COX2/LTs/IL-6 signaling, its gastroprotective action is preferentially potentiated by celecoxib.

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关键词

Cyclooxygenase,Gastric damage,Inflammation,Montelukast,NSAIDs,Paw inflammation

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