Transition-metal-free mono- or dinitration of protected anilines

Enrui Dai,Yongrui Dong,Rui Kong, Guangzhang Liu,Ying Dong,Qiong Wu,Deqiang Liang,Yinhai Ma

SYNTHETIC COMMUNICATIONS（2020）

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摘要

An amide-assisted arene nitration is presented, and both mono- and dinitration of protected anilines could be effected by using NaNO2 and NaNO3 as the mono- and bisnitrating agents, respectively. This divergent synthesis is transition-metal- and acid-free, and features a broad substrate scope, low cost, and ortho-para selectivity.

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关键词

Amide-assisted strategy,anilides,C - H functionalization,divergent synthesis,radical reaction

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