A Facile Approach to the Synthesis of Benzothiazoles from N -Protected Amino Acids

–A simple trituration method for the synthesis of 2-substituted benzothiazoles derived from N -protected amino acids and 2-aminothiophenol using molecular iodine as a mild Lewis acid catalyst has been proposed. The reaction occurs in one step for 20–25 min in solve-free conditions and provides the target products in excellent yields.