ADTRP regulates TFPI expression via transcription factor POU1F1 involved in coronary artery disease.
Gene(2020)
摘要
•CAD susceptibility gene ADTRP significantly increases transcription activation of TFPI via transcription factor POU1F1.•POU1F1 interacts with the ADTRP-response element at the TFPI promoter/regulatory region.•The ADTRP-response element is required for dose-dependent transcription activation of TFPI.•Genomic variants of POU1F1are significantly associated with risk of CAD.•PhenGWA identifies other phenotypic traits associated with the ADTRP-POU1F1-TFPI signaling hub.
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关键词
CAD,ADTRP,TFPI,POU1F1,ChIP,FBS,TSS,PCR,TF,EMSA
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