Epitopes with similar physicochemical properties contribute to cross reactivity between peanut and tree nuts.

•Allergen peptides with similar PhysicoChemical Properties (PCP) can bind IgE.•An IgE epitope PCP-consensus identified similar repeats in diverse plant allergens.•Synthetic consensus peptide (cp) inhibited patient IgE binding to nut extracts.•cp antibodies preferentially bound to allergens containing multiple PCP repeats.•These repeats may contribute to cross reactions and the severity of nut allergies.