GAMMA-LINOLENIC ACID ALTERS MIGRATION, PROLIFERATION AND APOPTOSIS IN HUMAN AND RAT GLIOBLASTOMA CELLS.

Juliano Andreoli Miyake,Renata Nascimento Gomes,Alison Colquhoun

Prostaglandins & Other Lipid Mediators（2020）

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摘要

•Gamma-linolenic acid alters glioblastoma multiforme cell behavior.•Gamma-linolenic acid shows to inhibit GBM cells (human and rat) proliferation and migration.•Gamma-linolenic acid increased apoptosis in GBM cells (human and rat).•Gamma-linolenic acid has promising therapeutic potential in GBM altering PGE synthesis.

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关键词

AA,BSA,COX-2,CYP,ECM,GBM,GLA,LOX,MMP,PG,PGE2,PI3K,PUFA

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