Plasma kinetics of mature PCSK9, furin-cleaved PCSK9, and Lp(a) with or without administration of PCSK9 inhibitors in acute myocardial infarction

Akihiro Nakamura,Masanori Kanazawa,Yuta Kagaya,Masateru Kondo,Kenjiro Sato,Hideaki Endo,Eiji Nozaki

Journal of Cardiology（2020）

引用 11|浏览7

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摘要

•Transient upregulation of mature and furin-cleaved circulating proprotein convertase subtilisin/kexin type 9 (PCSK9) in acute myocardial infarction (MI).•Persistent, significant increase of plasma mature PCSK9 levels by PCSK9 inhibitor.•Decrease in plasma furin-cleaved PCSK9 levels by PCSK9 inhibitor.•Increased plasma lipoprotein(a) levels and significant inhibition in acute MI.

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关键词

Acute myocardial infarction,Evolocumab,Lipoprotein(a),Low-density lipoprotein cholesterol,Pharmacokinetic change,Proprotein convertase subtilisin/kexin type 9

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