Rasch analysis of the PANSS negative subscale and exploration of negative symptom trajectories in first-episode schizophrenia - data from the OPTiMiSE trial.

Lone Baandrup,Peter Allerup,Mette Ø Nielsen,Nikolaj Bak,Signe W Düring,Stefan Leucht,Silvana Galderisi,Armida Mucci,Paola Bucci,Celso Arango,Covadonga M Díaz-Caneja,Paola Dazzan,Philip McGuire,Arsime Demjaha,Bjørn H Ebdrup,René S Kahn,Birte Y Glenthøj

Psychiatry Research（2020）

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摘要

•We evaluated first-episode PANSS data from the OPTiMiSE trial.•Scalability of the PANSS negative subscale was assessed using Rasch analysis.•Results showed insufficient psychometric properties.•An exploratory approach was applied to define negative symptom trajectories.

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关键词

Item response theory,Rating scale,Composite score,Treatment response,Symptom relief

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