Angiotensin (1-7) through modulation of the NMDAR-nNOS-NO pathway and serotonergic metabolism exerts an anxiolytic-like effect in rats.

Donglin Zhu, Ming Sun,Qinqin Liu,Yu Yue,Jie Lu,Xingjian Lin,Jingping Shi

Behavioural Brain Research（2020）

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摘要

•Ang (1–7) exerted anxiolytic effects through modulation of NMDAR signaling.•Ang (1–7) promoted serotonergic metabolism through NO.•Ang (1–7) stimulated NO production through NMDAR-dependent nNOS activation.•Ang (1–7) is a promising anxiolytic drug with no severe adverse effects.

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关键词

Angiotensin (1–7),N-Methyl-d-aspartate receptor,Nitric oxide,Monoamine oxidase,Anxiety

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